Sep 29, 2020

Does having sleep apnea mean you’ll develop Alzheimer’s?

A new study conducted by Australian and Icelandic researchers has confirmed a long-suspected link between sleep apnea and the development of Alzheimer’s disease. 

While the cause of Alzheimer’s disease is still a mystery, the study found that amyloid plaques, which are toxic to brain cells, start in the same place and spread in the same way in the brains of people with sleep apnea, as they do in the brains of people with Alzheimer’s. 

The amyloid plaques are known indicators of Alzheimer’s disease, and lead investigator, Professor Stephen Robinson said that while scientists have known that the two diseases are related, they have been unable to confirm a connection. 

“We know that if you have sleep apnea in mid-life, you’re more likely to develop Alzheimer’s when you’re older, and if you have Alzheimer’s you are more likely to have sleep apnea than other people your age,” he said.

“The connection is there but untangling the causes and biological mechanisms remains a huge challenge.

“Our study is the first to find Alzheimer’s-like amyloid plaques in the brains of people with clinically-verified obstructive sleep apnea.

“It’s an important advance in our understanding of the links between these conditions and opens up new directions for researchers striving to develop therapies for treating, and hopefully preventing, Alzheimer’s disease.”

Another similarity between the two diseases that has been found is a correlation between the build-up of amyloid plaques and the severity of the diseases. And while the treatment of sleep apnea with continuous positive airway pressure (CPAP) is the most common approach to ease the day-to-day symptoms of sleep apnea, like disturbed sleep and helping to prevent breathing interruptions during sleep, researchers have found that using CPAP machines showed no difference in preventing the buildup of these toxic plaques on the brain. 

Other studies into dementia in the United States of America have developed new and inexpensive screening for dementia. The new sleep study, by Harvard University and affiliates, creates a Brain Age Index (BAI) which ages the brain to tell researchers whether there has been premature ageing, or whether the person has the potential to develop ageing that results in dementia. 

The test produces an estimate in the difference between the chronological age and the biological age of the person’s brain. By using an electroencephalogram (EEG) to take electrical measurements during the person’s sleep, the machine can estimate the age difference, and tell us whether the person is suffering from a deviation from normal brain ageing. This deviation could signify the presence and severity of dementia. 

“The model computes the difference between a person’s chronological age and how old their brain activity during sleep ‘looks,’ to provide an indication of whether a person’s brain is aging faster than is normal,” said senior author M. Brandon Westover, investigator in the Department of Neurology at MGH and director of Data Science at the MGH McCance Center for Brain Health. 

“This is an important advance, because before now it has only been possible to measure brain age using brain imaging with magnetic resonance imaging, which is much more expensive, not easy to repeat, and impossible to measure at home,” added Elissa Ye, the first author of the study and a member of Westover’s laboratory.

With more than 936 million people worldwide and up to 30% of older people living with sleep apnea, finding and confirming these types of links is a useful step in the ongoing studies into how to prevent and ease the effects of Alzheimer’s and dementia on the world’s ageing populations.

Leave a Reply

Your email address will not be published. Required fields are marked *

Advertisement
Advertisement
Advertisement

Aged care residents are “very lonely”, royal commission hears

  One of the nation’s leading dementia experts and a widely respected dementia advocate addressed the royal commission on Friday, explaining the challenges they see in the aged care sector and dementia care, and the solutions they propose. Professor Henry Brodaty, Scientia Professor at the Centre for Healthy Brain Ageing at the University of New... Read More

How your vision can predict dementia 12 years before it is diagnosed – new study

Visual issues may be an early indicator of cognitive decline as the toxic amyloid plaques associated with Alzheimer’s disease may first affect areas of the brain associated with vision, with parts of the brain associated with memory becoming damaged as the disease progresses. Read More

“Benzos” Linked to a 41% Increased Mortality Risk in Alzheimer’s Disease

Benzodiazepines or “Benzos” are a group of drugs called minor tranquillisers. These drugs are prescribed by a doctor to help people with anxiety or sleep problems. This class of drug is often prescribed to people with Alzheimer’s disease, however, a new study suggests that such drugs may increase the risk of death. A new study... Read More
Advertisement